Our Microbiome ,Shaping Diet

Throughout our lives we continue to shape our microbiome. In fact, I see them in life as the date of your exposure, as puberty. Pharmaceuticals, diet, infections, sex hormones, even environmentally toxic substances can act as selective pressures that contain microbes and what they are producing and therefore how they interact with the host. ۔ And really rein to reinforce it. And add to the complexity, if we focus on one point in time, not all microbiomes are equal. In this case, the study of gut microbiome in developing and developing adults. Here in red and green, we surpass the microbiome of the Malawian and American populations. We have the American population in blue. And basically every single place is what kind of bacteria are present in the gut microbiome of these people and how do we work with the data that we say that the microbiome profile of our cocourt How similar it is to all other microbiome profiles. And we calculate a distance.

 How similar it is, how close it is to how many microbes they have and how many of them there are, how many of them there are. And that's just the concept of calculating that distance. So if we have two spots in this study representing two gut microbiomes of individuals who are planning together, it means that the two gut microbiomes are similar to each other. But from what you can clearly see in it, is this American gut microbiome very different from the population of Meridianand and Malawi? And although Malawianand's marine population is on two different continents, in these less developed countries their gut microbiome is more like each other than the gut microbiome of the American population. To bolster what we have submitted to our microbiome in the United States, it is only looking at the types of bacteria that have been found to have acrostatic populations. We have drastically reduced the diversity of the American population and the number of different types of bacteria compared to less developed countries. And what's really amazing about this research is that we're getting clues as to why this is happening. When the shotgun metagenomics with the study found all the genes and pathways and these microbiomes, what was really the difference between these populations, which was really amazing, is that the adults of Amerindian and Malvian are really richer for alpha amylase. Were Therefore, it is an enzyme that breaks down complex plant polysaccharides. Therefore, the food included in the population of Malawi and Marinden is basically a plant polysaccharide, which is a plant based food. In the American population, we see simple sugars enriching the microbial metabolic pathways to advance. 

Found in processed foods, as we all know. So at least one feature, one thing we know about them is that they're running the sects in the gut microbiome that we use to find these populist sects in nutrition. And it was also recently strengthened by Pete Turnbull, a faculty member here. It was a study of 10 really amazing diets. And what Peter did was take those people and see how a plant-based animal-based diet can actually affect a healthy gut microbiome. And here we are showing the amount of fiber in the diet of these people before starting the study, then they got four days of plant based diet, the other participants got four days of animal based diet and as you would expect plants Dietary or plant-based fiber content Polysaccharide content is very high in an animal-based diet that is very low. In addition, plant-based foods have a higher fat content than animal-based diets, and the protein content of these two diets is also dramatically different, and they may be able to detect that these important nutrients Plant-based food is really transmitted with the identification of other animals. Food based What was really amazing was that when Peter calculated the distance again, how similar they were to the microbiomes of these individuals after they started their plant-based diet before they started their plant-based diet, really much There was no way to change. Plant-based foods do not really affect the gut microbiome. 

In contrast, diet-based diet introductions really add to that distance. And what it tells us is that the microbiome is very different from the microbiome that was not there before the introduction of plant-based foods. But it's not just about the synthesis of the microbiome that matters. The study also found that you change the molecular output of thyrobiome by changing your diet. And we can see here that in plant-based diets, in animal-based diuretics, tokyo-short chain fatty acid acetate and butyrate have been significantly reduced. And it makes sense because they are the fiber products of microbial fermenting plants. And what's really important is that short-chain fatty acids are very important Sources of energy are the cells that connect the intestines, they are anti-inflammatory and they have anti-inflammatory properties. And we think they have these activities because we have mutated with microbes that have traditionally incorporated our plant-based food into the smaller molecules that extinguish inflammation and improve the health of the system. Promote And with that, I'm sure you won't be surprised to learn that increasing levels of disease are related to the microbiome. And for example, things like skin disease are disturbed in dermatological conditions like psoriasis. But what is really interesting is that we are now saying that conditions like obesity are also linked to gut microbiome mutation.

 But the most amazing thing is that we are looking for conditions that are very difficult to treat and that we are not really connected to the disruption of the hit microbiome like depression and an autism spectrum disorder. To suggest that the gut microbiome may actually affect distant organs. And here are a couple of important seminal studies that have shown this. They have shown that disturbances associated with microbiome are also associated with vasculitis spectrum disorder and heart disease. But the important thing is that these studies have shown that these are microbial metabolites, microbial products that are responsible for these disorders and most of this work has been done in mice with follow-up work in humans. So it suggests that Thugt is not like Vegas, what happens in Gutdos doesn't live in the gut. It actually enters the circulation of these tiny molecules, and perhaps some of them are things that can cause the germs themselves to actually migrate to tour sites throughout the body and alter the physiology of the organs there. Helps to improve the health of remote organs.